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Does spironolactone cause kidney problems? Spironolactone may worsen kidney function in patients with low to no salt in their body or in those who take other blood pressure medicines (eg, ARB, ACE inhibitor). These conditions may cause you to lose too much water or salt and may lead to low blood pressure.
Why does spironolactone cause weight gain? Spironolactone works as a diuretic, which means that it causes the body to remove extra fluid. Reducing fluid in the body can result in body weight loss. As a result, some doctors prescribe spironolactone for women who develop bloating and weight gain from water retention due to PMS.
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