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Check the labels on all your medicines (such as cough-and-cold products, diet aids, or NSAIDs such as ibuprofen, naproxen) because they may contain ingredients that could increase your blood pressure or worsen your heart failure.
If intolerable adverse effects occur, consider dosage reduction; if adverse effects worsen or fail to resolve, may need to discontinue and switch to another antihypertensive drug class.
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Fagher B, Katzman P, Hulthen UL, et al "Antihypertensive efficacy and tolerability of enalapril and slow-release verapamil in essential hypertension: a double-blind, cross-over study.
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Although the relative reductions in total mortality and mortality from cardiovascular causes were smaller in the Prevention Trial (8 percent and 12 percent, respectively) than in the previously reported Treatment Trial (16 percent and 18 percent, respectively), the direction of the effects was similar in both trials.
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Once-daily antihypertensive dosing provides favorable 24-hour BP control compared with multiple daily doses.
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We compared the effects of atenolol (50 mg), amlodipine (5 mg), enalapril (20 mg), hydrochlorothiazide (25 mg), and losartan (50 mg) given in once-daily oral doses on office and ambulatory blood pressures (BPs) in patients with hypertension and obstructive sleep apnea (OSA).
Angiotensinergic versus nonangiotensinergic hemodynamic effects of converting enzyme inhibition in patients with chronic heart failure: assessment by acute renin and converting enzyme inhibition.
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More recently, Kantola and coworkers repeated their study with the same design, but analyzed 24-h BP profiles of 15 obese hypertensive patients with sleep apnea ().
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The expected result from finding and characterizing the genes that control BP is the gaining of insights into the etiology of hypertension.
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All of these subjects were recruited from the outpatient department of The State University of New York Health Science Center in Brooklyn, New York and Westchester Medical Center, Valhalla, New York.
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