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The phenothiazines, a class of medication that includes low-potency antipsychotics such as chlorpromazine (Thorazine), the first FGA approved and marketed by the US Food and Drug Administration (FDA), have a propensity to cause more hypotension, more anticholinergic side effects, and lower the seizure threshold, compared to FGAs such as haloperidol.
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Benefit-Risk Assessment of Atypical Antipsychotics in the Treatment of Schizophrenia and Comorbid Disorders in Children and Adolescents.
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After the Lilly study was published, spokespersons for Janssen Research Foundation from New Jersey and Belgium criticized not only the high risperidone dosages, but the statistical methods employed in the study (Gheuens and Grebb, 1998).
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In 1985, during studies on tuberoinfundibular-GABA (TI-GABA) system, 800 mg oral valproate was found to decrease prolactin concentrations in 20 healthy women, the lack of effect in schizophrenic patients supporting the hypothesis of a defect of the TI-GABA system in chronic schizophrenia ().
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We will wrap up our discussion of tyrosine supplementation for treating ADHD in the next few blog posts.
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The observation that systemic administration of specific histamine-H2 agonist (impromidine) is not able to avoid the cimetidine-induced prolactin release, while pre-treatment with benzodiazepines or GABA respectively suppressed or reduced prolactin response, suggested that cimetidine does not induce prolactin hypersecretion through an action on histamine H2 receptors, but through the interaction with other neurotransmitters, such as the pituitaric GABA-ergic system () ().
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Response to: A Commentary on “Antipsychotic-Induced Parkinsonism is Associated with Working Memory Deficits in Schizophrenia-Spectrum Disorders”.
The most common and potentially remediable cause of treatment failure in patients with schizophrenia is lack of adherence to prescribed oral medications.
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